Evaluation of 18F-nifene binding to α4β2 nicotinic receptors in the rat brain using microPET imaging
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چکیده
منابع مشابه
Evaluation of 18F-nifene binding to α4β2 nicotinic receptors in the rat brain using microPET imaging
MicroPET imaging studies using (18)F-nifene, a new positron emission tomography (PET) radiotracer for nicotinic acetylcholinergic receptors (nAChR) α4β2 receptors in rats, have been carried out. Rats were imaged for 90 min after intravenous injection of (18)F-nifene (0.8 to 1 mCi), and binding potential (BP(ND)) was measured. (18)F-Nifene binding to thalamic and extrathalamic brain regions was ...
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Nicotinic acetylcholine receptors (nAChRs) in the brain are important for cognitive function; however, their specific role in relevant brain regions remains unclear. In this study, we used the novel compound ¹⁸F-nifene to examine the distribution of nAChRs in the rat forebrain, and for individual animals related the results to behavioral performance on an auditory-cognitive task. We first show ...
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ژورنال
عنوان ژورنال: EJNMMI Research
سال: 2011
ISSN: 2191-219X
DOI: 10.1186/2191-219x-1-6